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Unlike steroid hormones, lipid insoluble hormones do not directly affect the target cell because they cannot enter the cell and act directly on DNA. However, lipids are very useful molecules for binding hormones, as they contain long chains of carbon, hydrogen and oxygen atoms. The mechanism of action of estrogen-like hormones The mechanism of action of estrogens varies from hormone to hormone. Estrogens are generally thought to bind and activate specific enzymes in the DNA. The effect depends on the target cell with regard to its metabolism. Hormones act in the body because they bind tightly to different kinds of genetic material. The target cells do two things when they receive the hormone (the first step is called transcytosis) by virtue of being on the same DNA chromosome as the hormone. The first is that the transcytosis molecule is transported from the cell that has the hormone binding site inside of it to the cell that is supposed to receive it – or vice versa. The second step is that the transcytosis molecule is broken apart and transported to the cell at the other end where it makes a chemical change. The hormone molecule and its receptors can now make their way into the cell (the second step called covalent change). The molecule has the same atoms as its receptor with the exception that it has new "bodies" of different atoms. Each of these new bodies carries information about the hormone that the receptor had before, or could transmit as well. When that new molecule enters a cell, it is activated (it activates an enzyme). The activated enzyme converts the hormone molecule to estrogen, which can bind to the receptor for the hormone and thereby alter the activity of the receptor. In addition, a change in the hormone receptor can also be used as a signal that can cause the cell to make new hormones. The two steps (transcytosis and covalent change) make up the complex step of estradiol's mechanism of action. Estrogens bind to DNA To bind to a particular RNA, which is known as a target RNA or target RNA, a molecule called a nucleotide is "cleaved" from its base by a DNA enzyme called a "covalent amino acid carboxylase" (NAC). NAC is located very close to the DNA and makes some of the amino acids that are usually found in the target RNA. When there is a mismatch between the amino acids that are bound to the target RNA and what is expected in a messenger RNA (mRNA), the nucleotide binding takes place at the other end of the strand of DNA that is Similar articles: